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Substrate Stiffness affects Sarcomere and Costamere Structure and Electrophysiological Function of Isolated Adult Cardiomyocytes

INTRODUCTION: The mechanical environment is a key regulator of function in cardiomyocytes. We studied the role of substrate stiffness on the organization of sarcomeres and costameres in adult rat cardiomyocytes, and further examined the resulting changes in cell shortening and calcium dynamics. METH...

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Detalhes bibliográficos
Main Authors: Galie, Peter A., Khalid, Nashmia, Carnahan, Kelly E., Westfall, Margaret V., Stegemann, Jan P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610795/
https://ncbi.nlm.nih.gov/pubmed/23266222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carpath.2012.10.003
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