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Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans

Prion proteins can adopt self-propagating alternative conformations that account for the infectious nature of transmissible spongiform encephalopathies (TSEs) and the epigenetic inheritance of certain traits in yeast. Recent evidence suggests a similar propagation of misfolded proteins in the spread...

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Detalhes bibliográficos
Main Authors: Nussbaum-Krammer, Carmen I., Park, Kyung-Won, Li, Liming, Melki, Ronald, Morimoto, Richard I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610634/
https://ncbi.nlm.nih.gov/pubmed/23555277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003351
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