Polyanionic Candidate Microbicides Accelerate the Formation of Semen-Derived Amyloid Fibrils to Enhance HIV-1 Infection

Polyanionic candidate microbicides, including cellulose sulfate, carrageenan, PRO 2000, were proven ineffective in preventing HIV-1 transmission and even cellulose sulfate showed increased risk of HIV acquisition in the Phase III efficacy trials. Semen plays critical roles in HIV-1 sexual transmissi...

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Detalhes bibliográficos
Main Authors: Tan, Suiyi, Lu, Lu, Li, Lin, Liu, Jixiang, Oksov, Yelena, Lu, Hong, Jiang, Shibo, Liu, Shuwen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609764/
https://ncbi.nlm.nih.gov/pubmed/23544097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059777
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