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Evidence from a Randomized Trial That Simvastatin, but Not Ezetimibe, Upregulates Circulating PCSK9 Levels

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted inhibitor of the low-density lipoprotein (LDL) receptor and an important regulator of LDL metabolism. Elevated PCSK9 levels have been associated with cardiovascular risk. The purpose of this study was to investigate how...

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Bibliografiske detaljer
Main Authors: Berthold, Heiner K., Seidah, Nabil G., Benjannet, Suzanne, Gouni-Berthold, Ioanna
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609731/
https://ncbi.nlm.nih.gov/pubmed/23544125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060095
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