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Association of catalytic and regulatory subunits of cyclic AMP-dependent protein kinase requires a negatively charged side group at a conserved threonine.

In Saccharomyces cerevisiae, as in higher eucaryotes, cyclic AMP (cAMP)-dependent protein kinase is a tetramer composed of two catalytic (C) subunits and two regulatory (R) subunits. In the absence of cAMP, the phosphotransferase activity of the C subunit is inhibited by the tight association with R...

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Detalles Bibliográficos
Publicado en:Mol Cell Biol
Principais autores: Levin, L R, Zoller, M J
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 1990
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360967/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2106066/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.3.1066-1075.1990
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