Cyclic AMP-dependent protein kinase I: Cyclic nucleotide binding, structural changes, and release of the catalytic subunits

Type I cyclic AMP (cAMP)-dependent protein kinase is composed of a dimeric regulatory subunit (R(2)) and two catalytic subunits (C subunits). The R(2) dimer binds four cAMP molecules to release the two C subunits. To characterize the cAMP binding sites and elucidate their role in the release of the...

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Bibliographic Details
Main Authors: Smith, Stephen B., White, Hillary D., Siegel, Jeffrey B., Krebs, Edwin G.
Format: Artigo
Language:Inglês
Published: 1981
Subjects:
Biological Sciences: Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC319177/
https://ncbi.nlm.nih.gov/pubmed/6262817
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