Cyclic AMP-dependent protein kinase I: Cyclic nucleotide binding, structural changes, and release of the catalytic subunits

Type I cyclic AMP (cAMP)-dependent protein kinase is composed of a dimeric regulatory subunit (R(2)) and two catalytic subunits (C subunits). The R(2) dimer binds four cAMP molecules to release the two C subunits. To characterize the cAMP binding sites and elucidate their role in the release of the...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Smith, Stephen B., White, Hillary D., Siegel, Jeffrey B., Krebs, Edwin G.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1981
Soggetti:	Biological Sciences: Biochemistry
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6262817/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.3.1591
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