Liver-Specific Disruption of the Murine Glucagon Receptor Produces α-Cell Hyperplasia: Evidence for a Circulating α-Cell Growth Factor

Glucagon is a critical regulator of glucose homeostasis; however, mechanisms regulating glucagon action and α-cell function and number are incompletely understood. To elucidate the role of the hepatic glucagon receptor (Gcgr) in glucagon action, we generated mice with hepatocyte-specific deletion of...

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Main Authors: Longuet, Christine, Robledo, Ana M., Dean, E. Danielle, Dai, Chunhua, Ali, Safina, McGuinness, Ian, de Chavez, Vincent, Vuguin, Patricia M., Charron, Maureen J., Powers, Alvin C., Drucker, Daniel J.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2013
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609565/
https://ncbi.nlm.nih.gov/pubmed/23160527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1605
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