Dissociation of Bcl-2–Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes

Diabetic cardiomyopathy is associated with suppression of cardiac autophagy, and activation of AMP-activated protein kinase (AMPK) restores cardiac autophagy and prevents cardiomyopathy in diabetic mice, albeit by an unknown mechanism. We hypothesized that AMPK-induced autophagy ameliorates diabetic...

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Bibliographic Details
Main Authors: He, Chaoyong, Zhu, Huaiping, Li, Hongliang, Zou, Ming-Hui, Xie, Zhonglin
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2013
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609561/
https://ncbi.nlm.nih.gov/pubmed/23223177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0533
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