Fetal PGC-1α Overexpression Programs Adult Pancreatic β-Cell Dysfunction

Adult β-cell dysfunction, a hallmark of type 2 diabetes, can be programmed by adverse fetal environment. We have shown that fetal glucocorticoids (GCs) participate in this programming through inhibition of β-cell development. Here we have investigated the molecular mechanisms underlying this regulat...

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Detalhes bibliográficos
Main Authors: Valtat, Bérengère, Riveline, Jean-Pierre, Zhang, Ping, Singh-Estivalet, Amrit, Armanet, Mathieu, Venteclef, Nicolas, Besseiche, Adrien, Kelly, Daniel P., Tronche, François, Ferré, Pascal, Gautier, Jean-François, Bréant, Bernadette, Blondeau, Bertrand
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609553/
https://ncbi.nlm.nih.gov/pubmed/23274887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0314
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