Novel Transgenic Mice for Inducible Gene Overexpression in Pancreatic Cells Define Glucocorticoid Receptor-Mediated Regulations of Beta Cells

Conditional gene deletion in specific cell populations has helped the understanding of pancreas development. Using this approach, we have shown that deleting the glucocorticoid receptor (GR) gene in pancreatic precursor cells leads to a doubled beta-cell mass. Here, we provide genetic tools that per...

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Detalhes bibliográficos
Main Authors: Blondeau, Bertrand, Sahly, Iman, Massouridès, Emmanuelle, Singh-Estivalet, Amrit, Valtat, Bérengère, Dorchene, Delphine, Jaisser, Frédéric, Bréant, Bernadette, Tronche, Francois
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281827/
https://ncbi.nlm.nih.gov/pubmed/22363422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030210
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