Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain.

Malignant activation of the human trk proto-oncogene, a member of the tyrosine protein kinase receptor family, has been implicated in the development of certain human cancers, including colon and thyroid papillary carcinomas. trk oncogenes have also been identified in cultured cells transfected with...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Coulier, F, Kumar, R, Ernst, M, Klein, R, Martin-Zanca, D, Barbacid, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360953/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1695324/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.8.4202-4210.1990
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