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Paneth Cells and Necrotizing Enterocolitis: A novel hypothesis for disease pathogenesis

Current models of necrotizing enterocolitis (NEC) propose intraluminal microbes destroy intestinal mucosa and activate an inflammatory cascade that ends in necrosis. We suggest an alternate hypothesis wherein NEC is caused by injury to Paneth cells (PCs) in the intestinal crypts. PCs are specialized...

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Autores principales: McElroy, Steven J., Underwood, Mark A., Sherman, Michael P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609425/
https://ncbi.nlm.nih.gov/pubmed/23006982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000342340
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