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Dysfunction of microtubule-associated proteins of MAP2/tau family in Prion disease
The aggregation of PrP(Sc) is thought to be crucial for the neuropathology of prion diseases. A growing body of evidence demonstrates that the perturbation of the microtubule network contributes to PrP(Sc)-mediated neurodegeneration. Microtubules are a component of the cytoskeleton and play a centra...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3609059/ https://ncbi.nlm.nih.gov/pubmed/22874672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.20677 |
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