The CARD8 p.C10X mutation associates with a low anti-glycans antibody response in patients with Crohn’s disease

BACKGROUND: Crohn’s disease (CD) is associated with elevated anti-glycans antibody response in 60% of CD patients, and 25% of healthy first-degree relatives (HFDRs), suggesting a genetic influence for this humoral response. In mice, anti-glucan antibody response depends on the NLRP3 inflammasome. He...

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Autori principali: Vasseur, Francis, Sendid, Boualem, Broly, Franck, Gower-Rousseau, Corinne, Sarazin, Aurore, Standaert-Vitse, Annie, Colombel, Jean-Frederic, Poulain, Daniel, Jouault, Thierry
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608972/
https://ncbi.nlm.nih.gov/pubmed/23506543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-14-35
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