Early Interneuron Dysfunction in ALS: Insights from a Mutant sod1 Zebrafish Model

OBJECTIVE: To determine, when, how, and which neurons initiate the onset of pathophysiology in amyotrophic lateral sclerosis (ALS) using a transgenic mutant sod1 zebrafish model and identify neuroprotective drugs. METHODS: Proteinopathies such as ALS involve mutant proteins that misfold and activate...

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Main Authors: McGown, Alexander, McDearmid, Jonathan R, Panagiotaki, Niki, Tong, Huaxia, Al Mashhadi, Sufana, Redhead, Natasha, Lyon, Alison N, Beattie, Christine E, Shaw, Pamela J, Ramesh, Tennore M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608830/
https://ncbi.nlm.nih.gov/pubmed/23281025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23780
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