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Antigen choice determines vaccine-induced generation of immunogenic versus tolerogenic DC that are marked by differential expression of pancreatic enzymes()
Dendritic cells (DC) elicit immunity to pathogens and tumors while simultaneously preserving tolerance to self. Efficacious cancer vaccines have been a challenge because they are based on tumor antigens, some of which are self-antigens and thus subject to self-tolerance. One such antigen is the tumo...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608825/ https://ncbi.nlm.nih.gov/pubmed/23420890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203321 |
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