Genetic interactions among Idd3, Idd5.1, Idd5.2 and Idd5.3 protective loci in the NOD mouse model of type 1 diabetes

In the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D), insulin-dependent diabetes (Idd) loci control the development of insulitis and diabetes. Independently, protective alleles of Idd3/Il2 or Idd5 are able to partially protect congenic NOD mice from insulitis and diabetes, and to part...

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Main Authors: Lin, Xiaotian, Hamilton-Williams, Emma E., Rainbow, Daniel B, Hunter, Kara M., Dai, Yang D., Cheung, Jocelyn, Peterson, Laurence B., Wicker, Linda S., Sherman, Linda A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608810/
https://ncbi.nlm.nih.gov/pubmed/23427248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203422
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