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Orai1 Function is Essential for T Cell Homing to Lymph Nodes

In T lymphocytes, Ca(2+) release-activated Ca(2+) (CRAC) channels composed of Orai1 subunits trigger antigen-induced gene expression and cell proliferation through the NFAT pathway. We evaluated the requirement of CRAC channel function for lymphocyte homing using expression of a dominant-negative Or...

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Bibliografiske detaljer
Main Authors: Greenberg, Milton L., Yu, Ying, Leverrier, Sabrina, Zhang, Shenyuan L., Parker, Ian, Cahalan, Michael D.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608704/
https://ncbi.nlm.nih.gov/pubmed/23455504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202212
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