Preferential Binding of Hot Spot Mutant p53 Proteins to Supercoiled DNA In Vitro and in Cells

Hot spot mutant p53 (mutp53) proteins exert oncogenic gain-of-function activities. Binding of mutp53 to DNA is assumed to be involved in mutp53-mediated repression or activation of several mutp53 target genes. To investigate the importance of DNA topology on mutp53-DNA recognition in vitro and in ce...

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Autori principali: Brázdová, Marie, Navrátilová, Lucie, Tichý, Vlastimil, Němcová, Kateřina, Lexa, Matej, Hrstka, Roman, Pečinka, Petr, Adámik, Matej, Vojtesek, Borivoj, Paleček, Emil, Deppert, Wolfgang, Fojta, Miroslav
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608670/
https://ncbi.nlm.nih.gov/pubmed/23555710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059567
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