Genetic Diversity and Lack of Artemisinin Selection Signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion

The recent detection of clinical Artemisinin (ART) resistance manifested as delayed parasite clearance in the Cambodia-Thailand border area raises a serious concern. The mechanism of ART resistance is not clear; but the P. falciparum sarco/endoplasmic reticulum Ca(2+)-ATPase (PfSERCA or PfATP6) has...

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Autori principali: Miao, Miao, Wang, Zenglei, Yang, Zhaoqing, Yuan, Lili, Parker, Daniel M., Putaporntip, Chaturong, Jongwutiwes, Somchai, Xangsayarath, Phonepadith, Pongvongsa, Tiengkham, Moji, Hazuhiko, Dinh Tuong, Trinh, Abe, Tomoko, Nakazawa, Shusuke, Kyaw, Myat Phone, Yan, Guiyun, Sirichaisinthop, Jeeraphat, Sattabongkot, Jetsumon, Mu, Jianbing, Su, Xin-zhuan, Kaneko, Osamu, Cui, Liwang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608609/
https://ncbi.nlm.nih.gov/pubmed/23555629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059192
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