Genetic Diversity and Lack of Artemisinin Selection Signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion

The recent detection of clinical Artemisinin (ART) resistance manifested as delayed parasite clearance in the Cambodia-Thailand border area raises a serious concern. The mechanism of ART resistance is not clear; but the P. falciparum sarco/endoplasmic reticulum Ca(2+)-ATPase (PfSERCA or PfATP6) has...

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Hauptverfasser: Miao, Miao, Wang, Zenglei, Yang, Zhaoqing, Yuan, Lili, Parker, Daniel M., Putaporntip, Chaturong, Jongwutiwes, Somchai, Xangsayarath, Phonepadith, Pongvongsa, Tiengkham, Moji, Hazuhiko, Dinh Tuong, Trinh, Abe, Tomoko, Nakazawa, Shusuke, Kyaw, Myat Phone, Yan, Guiyun, Sirichaisinthop, Jeeraphat, Sattabongkot, Jetsumon, Mu, Jianbing, Su, Xin-zhuan, Kaneko, Osamu, Cui, Liwang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608609/
https://ncbi.nlm.nih.gov/pubmed/23555629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059192
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