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Thrombin induces an inflammatory phenotype in a human brain endothelial cell line
In this study, we utilized the human brain endothelial cell line, hCMEC/D3, to determine the effects of the coagulation factor, thrombin, on the human blood–brain barrier (BBB). We show that thrombin increased the mRNA and cell surface levels of ICAM-1 and VCAM-1 in hCMEC/D3 cells. Thrombin similarl...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608467/ https://ncbi.nlm.nih.gov/pubmed/22381244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2012.02.004 |
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