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Genetic Correction of Huntington’s Disease Phenotypes in Induced Pluripotent Stem Cells
Huntington’s disease (HD) is caused by a CAG expansion in the huntingtin gene. Expansion of the polyglutamine tract in the huntingtin protein results in massive cell death in the striatum of HD patients. We report that human induced pluripotent stem cells (iPSCs) derived from HD patient fibroblasts...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608272/ https://ncbi.nlm.nih.gov/pubmed/22748967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.04.026 |
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