Genetic Correction of Huntington’s Disease Phenotypes in Induced Pluripotent Stem Cells

Huntington’s disease (HD) is caused by a CAG expansion in the huntingtin gene. Expansion of the polyglutamine tract in the huntingtin protein results in massive cell death in the striatum of HD patients. We report that human induced pluripotent stem cells (iPSCs) derived from HD patient fibroblasts...

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Hlavní autoři: An, Mahru C., Zhang, Ningzhe, Scott, Gary, Montoro, Daniel, Wittkop, Tobias, Mooney, Sean, Melov, Simon, Ellerby, Lisa M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608272/
https://ncbi.nlm.nih.gov/pubmed/22748967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.04.026
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