Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.
The human insulinlike growth factor I receptor was overexpressed in NIH 3T3 cells as well as human and rat primary fibroblast strains. The NIH 3T3 cells displayed a ligand-dependent, highly transformed phenotype. When exposed to insulinlike growth factor I or supraphysiologic levels of insulin, NIH...
Enregistré dans:
| Publié dans: | Mol Cell Biol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
1990
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360815/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2153917/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.2.464-473.1990 |
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