In Vivo DPP-4 Inhibition to Enhance Engraftment of Single-Unit Cord Blood Transplants in Adults with Hematological Malignancies

Delayed engraftment is a significant limitation of umbilical cord blood (UCB) transplantation due to low stem cell numbers. Inhibition of dipeptidyl peptidase (DPP)-4 enhanced engraftment in murine transplants. We evaluated the feasibility of systemic DPP-4 inhibition using sitagliptin to enhance en...

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Hlavní autoři: Farag, Sherif S., Srivastava, Shivani, Messina-Graham, Steven, Schwartz, Jennifer, Robertson, Michael J., Abonour, Rafat, Cornetta, Kenneth, Wood, Lisa, Secrest, Angie, Strother, R. Matthew, Jones, David R., Broxmeyer, Hal E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2013
Témata:
Clinical Trial
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607909/
https://ncbi.nlm.nih.gov/pubmed/23270493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2012.0636
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