Conversion of the lac repressor into an allosterically regulated transcriptional activator for mammalian cells.

A novel mammalian regulatory system was created by using the Escherichia coli lac repressor. The lac repressor was converted into a mammalian transcriptional activator by modifying the lac repressor coding region to include a nuclear localization signal from the simian virus 40 (SV40) large tumor an...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Labow, M A, Baim, S B, Shenk, T, Levine, A J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360756/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2162473/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.7.3343-3356.1990
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