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Improving T(1) and T(2) magnetic resonance imaging (MRI) contrast agents through the conjugation of an esteramide dendrimer to high water coordination Gd(III) hydroxypyridinone (HOPO) complexes

Commercial gadolinium magnetic resonance imaging (MRI) contrast agents are limited by low relaxivity (r(1)) and coordination to only a single water molecule (q = 1). Consequently, gram quantities of these agents must be injected to obtain sufficient diagnostic contrast. In this study, MRI contrast a...

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Détails bibliographiques
Auteurs principaux: Klemm, Piper J., Floyd, William C., Smiles, Danil E., Fréchet, Jean M. J., Raymond, Kenneth N.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607543/
https://ncbi.nlm.nih.gov/pubmed/22344885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmmi.483
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