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Conjugation Effects of Various Linkers on Gd(III) MRI Contrast Agents with Dendrimers: Optimizing the Hydroxypyridinonate (HOPO) Ligands with Nontoxic, Degradable Esteramide (EA) Dendrimers For High Relaxivity

[Image: see text] One essential requirement for more sensitive gadolinium-based MRI contrast agents is to slow the molecular tumbling of the gadolinium(III) ion, which increases the gadolinium's relaxivity, or the ability to speed up the NMR relaxation of nearby water molecules. One route to th...

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Detalhes bibliográficos
Main Authors: Floyd, William C., Klemm, Piper J., Smiles, Danil E., Kohlgruber, Ayano C., Pierre, Valerie C., Mynar, Justin L., Fréchet, Jean M. J., Raymond, Kenneth N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174241/
https://ncbi.nlm.nih.gov/pubmed/21294571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja110582e
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