Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex–Induced Arthritis

Factor H (fH) is an endogenous negative regulator of the alternative pathway (AP) that binds polyanions as well as complement activation fragments C3b and C3d. The AP is both necessary and sufficient to develop collagen Ab–induced arthritis (CAIA) in mice; the mechanisms whereby normal control of th...

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Bibliografiska uppgifter
Huvudupphovsmän: Banda, Nirmal K., Mehta, Gaurav, Ferreira, Viviana P., Cortes, Claudio, Pickering, Matthew C., Pangburn, Michael K., Arend, William P., Holers, V. Michael
Materialtyp: Artigo
Språk:Inglês
Publicerad: AAI 2013
Ämnen:
Innate Immunity and Inflammation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607402/
https://ncbi.nlm.nih.gov/pubmed/23436934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203271
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