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Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex–Induced Arthritis
Factor H (fH) is an endogenous negative regulator of the alternative pathway (AP) that binds polyanions as well as complement activation fragments C3b and C3d. The AP is both necessary and sufficient to develop collagen Ab–induced arthritis (CAIA) in mice; the mechanisms whereby normal control of th...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
AAI
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3607402/ https://ncbi.nlm.nih.gov/pubmed/23436934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203271 |
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