Impaired TLR5 Functionality Is Associated with Survival in Melioidosis

Melioidosis is infection caused by the flagellated saprophyte Burkholderia pseudomallei. TLR5 is a pathogen recognition receptor activated by bacterial flagellin. We studied a genetic variant that encodes a defective TLR5 protein, TLR5(1174C>T), to elucidate the role of TLR5 in melioidosis. We me...

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Autores principales: West, T. Eoin, Chantratita, Narisara, Chierakul, Wirongrong, Limmathurotsakul, Direk, Wuthiekanun, Vanaporn, Myers, Nicolle D., Emond, Mary J., Wurfel, Mark M., Hawn, Thomas R., Peacock, Sharon J., Skerrett, Shawn J.
Formato: Artigo
Lenguaje:Inglês
Publicado: AAI 2013
Materias:
Infectious Disease and Host Response
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607401/
https://ncbi.nlm.nih.gov/pubmed/23447684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202974
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