Molecular Model of a Soluble Guanylyl Cyclase Fragment Determined by Small-Angle X–ray Scattering and Chemical Cross-Linking

Soluble guanylyl/guanylate cyclase (sGC) converts GTP to cGMP after binding nitric oxide, leading to smooth muscle relaxation and vasodilation. Impaired sGC activity is common in cardiovascular disease and sGC stimulatory compounds are greatly sought. sGC is a 150 kDa heterodimeric protein with two...

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Autori principali: Fritz, Bradley G., Roberts, Sue A., Ahmed, Aqeel, Breci, Linda, Li, Wenzhou, Weichsel, Andrzej, Brailey, Jacqueline L., Wysocki, Vicki H., Tama, Florence, Montfort, William R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607398/
https://ncbi.nlm.nih.gov/pubmed/23363317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301570m
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