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Promotion of Caspase Activation by Caspase-9-mediated Feedback Amplification of Mitochondrial Damage

Mitochondrial disruption during apoptosis results in the activation of caspase-9 and a downstream caspase cascade. Triggering this caspase cascade leads to the cleavage of anti-apoptotic Bcl-2 family proteins, resulting in feedback amplification of mitochondrial disruption. However, whether such a f...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Guerrero, Alan D., Schmitz, Ingo, Chen, Min, Wang, Jin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607397/
https://ncbi.nlm.nih.gov/pubmed/23539542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2155-9899.1000126
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