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Promotion of Caspase Activation by Caspase-9-mediated Feedback Amplification of Mitochondrial Damage
Mitochondrial disruption during apoptosis results in the activation of caspase-9 and a downstream caspase cascade. Triggering this caspase cascade leads to the cleavage of anti-apoptotic Bcl-2 family proteins, resulting in feedback amplification of mitochondrial disruption. However, whether such a f...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3607397/ https://ncbi.nlm.nih.gov/pubmed/23539542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2155-9899.1000126 |
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