Vascular change measured with independent component analysis of dynamic susceptibility contrast MRI predicts bevacizumab response in high-grade glioma

BACKGROUND: Standard pre- and postcontrast (T1 + C) anatomical MR imaging is proving to be insufficient for accurately monitoring bevacizumab treatment response in recurrent glioblastoma (GBM). We present a novel imaging biomarker that detects abnormal tumor vasculature exhibiting both arterial and...

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Autores principales: LaViolette, Peter S., Cohen, Alex D., Prah, Melissa A., Rand, Scott D., Connelly, Jennifer, Malkin, Mark. G., Mueller, Wade. M., Schmainda, Kathleen M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
Materias:
Basic and Translational Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607265/
https://ncbi.nlm.nih.gov/pubmed/23382287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos323
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