Alteration of proteoglycan sulfation affects bone growth and remodeling

Diastrophic dysplasia (DTD) is a chondrodysplasia caused by mutations in the SLC26A2 gene, leading to reduced intracellular sulfate pool in chondrocytes, osteoblasts and fibroblasts. Hence, proteoglycans are undersulfated in the cartilage and bone of DTD patients. To characterize the bone phenotype...

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Hlavní autoři: Gualeni, Benedetta, de Vernejoul, Marie-Christine, Marty-Morieux, Caroline, De Leonardis, Fabio, Franchi, Marco, Monti, Luca, Forlino, Antonella, Houillier, Pascal, Rossi, Antonio, Geoffroy, Valerie
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Science 2013
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Original Full Length Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607217/
https://ncbi.nlm.nih.gov/pubmed/23369989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2013.01.036
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