Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma

Glypican-3 (GPC3) has emerged as a candidate therapeutic target in hepatocellular carcinoma (HCC), but the oncogenic role of GPC3 in HCC is poorly understood. Here, we report a human heavy-chain variable domain antibody, HN3, with high affinity (K(d) = 0.6 nM) for cell-surface–associated GPC3 molecu...

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Autors principals: Feng, Mingqian, Gao, Wei, Wang, Ruoqi, Chen, Weizao, Man, Yan-Gao, Figg, William Douglas, Wang, Xin Wei, Dimitrov, Dimiter S., Ho, Mitchell
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607002/
https://ncbi.nlm.nih.gov/pubmed/23471984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217868110
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