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Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
Endoplasmic reticulum (ER) stress sensors use a related luminal domain to monitor the unfolded protein load and convey the signal to downstream effectors, signaling an unfolded protein response (UPR) that maintains compartment-specific protein folding homeostasis. Surprisingly, perturbation of cellu...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3606975/ https://ncbi.nlm.nih.gov/pubmed/23487760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217611110 |
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