Blocking Type I Interferon Signaling Rescues Lymphocytes from Oxidative Stress, Exhaustion, and Apoptosis in a Streptozotocin-Induced Mouse Model of Type I Diabetes

Elevated levels of type I interferon (IFN) during type 1 diabetes mellitus (T1D) are associated with a defective immune response. In the present study, we investigated whether blocking type I IFN signaling during streptozotocin- (STZ-) induced T1D in mice improves lymphocyte proliferation and escape...

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Detalhes bibliográficos
Main Authors: Ibrahim, Hany M., El-Elaimy, Ibrahim A., Saad Eldien, Heba M., Badr, Badr Mohamed, Rabah, Danny M., Badr, Gamal
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606800/
https://ncbi.nlm.nih.gov/pubmed/23533683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/148725
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