The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness

During chronic viral infections and in cancer, T cells become dysfunctional, a state known as T cell exhaustion. Although it is well recognized that memory CD8 T cells account for the persistence of CD8 T cell immunity after acute infection, how exhausted T cells persist remains less clear. Using ch...

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Bibliographic Details
Published in:Sci Immunol
Main Authors: Wu, Tuoqi, Ji, Yun, Moseman, E. Ashley, Xu, Haifeng C., Manglani, Monica, Kirby, Martha, Anderson, Stacie M., Handon, Robin, Kenyon, Elizabeth, Elkahloun, Abdel, Wu, Weiwei, Lang, Philipp A., Gattinoni, Luca, McGavern, Dorian B., Schwartzberg, Pamela L.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179228/
https://ncbi.nlm.nih.gov/pubmed/28018990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aai8593
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