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The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness
During chronic viral infections and in cancer, T cells become dysfunctional, a state known as T cell exhaustion. Although it is well recognized that memory CD8 T cells account for the persistence of CD8 T cell immunity after acute infection, how exhausted T cells persist remains less clear. Using ch...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Sci Immunol |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5179228/ https://ncbi.nlm.nih.gov/pubmed/28018990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aai8593 |
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