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Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-alpha toxin antibody fragment and alpha toxin

Staphylococcus aureus alpha toxin (AT) has been crystallized in complex with the Fab fragment of a human antibody (MEDI4893). This constitutes the first reported crystals of AT bound to an antibody. The monoclinic crystals belonged to space group P2(1), with unit-cell parameters a = 85.52, b = 148.5...

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Hlavní autoři: Oganesyan, Vaheh, Barnes, Arnita, Tkaczyk, Christine, Ferguson, Andrew, Wu, Herren, Dall’Acqua, William F.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606579/
https://ncbi.nlm.nih.gov/pubmed/23519809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309113002881
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