Curcumin as a Potent and Selective Inhibitor of 11β-Hydroxysteroid Dehydrogenase 1: Improving Lipid Profiles in High-Fat-Diet-Treated Rats

BACKGROUND: 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) activates glucocorticoid locally in liver and fat tissues to aggravate metabolic syndrome. 11β-HSD1 selective inhibitor can be used to treat metabolic syndrome. Curcumin and its derivatives as selective inhibitors of 11β-HSD1 have not been re...

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Main Authors: Hu, Guo-Xin, Lin, Han, Lian, Qing-Quan, Zhou, Shu-Hua, Guo, Jingjing, Zhou, Hong-Yu, Chu, Yanhui, Ge, Ren-Shan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606385/
https://ncbi.nlm.nih.gov/pubmed/23533564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049976
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