Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression

BACKGROUND: Histone methyltransferase enhancer of zeste homologue 2 (EZH2) forms an obligate repressive complex with suppressor of zeste 12 and embryonic ectoderm development, which is thought, along with EZH1, to be primarily responsible for mediating Polycomb-dependent gene silencing. Polycomb-med...

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Autors principals: Grzenda, Adrienne, Lomberk, Gwen, Svingen, Phyllis, Mathison, Angela, Calvo, Ezequiel, Iovanna, Juan, Xiong, Yuning, Faubion, William, Urrutia, Raul
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606351/
https://ncbi.nlm.nih.gov/pubmed/23448518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-6-3
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