HIV Protease Inhibitors Disrupt Lipid Metabolism by Activating Endoplasmic Reticulum Stress and Inhibiting Autophagy Activity in Adipocytes

BACKGROUND: HIV protease inhibitors (PI) are core components of Highly Active Antiretroviral Therapy (HAART), the most effective treatment for HIV infection currently available. However, HIV PIs have now been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular d...

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Hlavní autoři: Zha, Beth S., Wan, Xiaoshan, Zhang, Xiaoxuan, Zha, Weibin, Zhou, Jun, Wabitsch, Martin, Wang, Guangji, Lyall, Vijay, Hylemon, Phillip B., Zhou, Huiping
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606318/
https://ncbi.nlm.nih.gov/pubmed/23533630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059514
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