HIV Protease Inhibitors Disrupt Lipid Metabolism by Activating Endoplasmic Reticulum Stress and Inhibiting Autophagy Activity in Adipocytes

BACKGROUND: HIV protease inhibitors (PI) are core components of Highly Active Antiretroviral Therapy (HAART), the most effective treatment for HIV infection currently available. However, HIV PIs have now been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular d...

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Main Authors: Zha, Beth S., Wan, Xiaoshan, Zhang, Xiaoxuan, Zha, Weibin, Zhou, Jun, Wabitsch, Martin, Wang, Guangji, Lyall, Vijay, Hylemon, Phillip B., Zhou, Huiping
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606318/
https://ncbi.nlm.nih.gov/pubmed/23533630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059514
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