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Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left–right patterning and heart development
Mutations in ZIC3 cause human X-linked heterotaxy and isolated cardiovascular malformations. A mouse model with targeted deletion of Zic3 demonstrates an early role for Zic3 in gastrulation, CNS, cardiac and left–right axial development. The observation of multiple malformations in Zic3(null) mice a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3606008/ https://ncbi.nlm.nih.gov/pubmed/23184148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds494 |
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