Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier

Cardiac triacylglycerol (TG) catabolism critically depends on the TG hydrolytic activity of adipose triglyceride lipase (ATGL). Perilipin 5 (Plin5) is expressed in cardiac muscle (CM) and has been shown to interact with ATGL and its coactivator comparative gene identification-58 (CGI-58). Furthermor...

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Main Authors: Pollak, Nina M., Schweiger, Martina, Jaeger, Doris, Kolb, Dagmar, Kumari, Manju, Schreiber, Renate, Kolleritsch, Stephanie, Markolin, Philipp, Grabner, Gernot F., Heier, Christoph, Zierler, Kathrin A., Rülicke, Thomas, Zimmermann, Robert, Lass, Achim, Zechner, Rudolf, Haemmerle, Guenter
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2013
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605985/
https://ncbi.nlm.nih.gov/pubmed/23345410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M034710
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