Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier

Cardiac triacylglycerol (TG) catabolism critically depends on the TG hydrolytic activity of adipose triglyceride lipase (ATGL). Perilipin 5 (Plin5) is expressed in cardiac muscle (CM) and has been shown to interact with ATGL and its coactivator comparative gene identification-58 (CGI-58). Furthermor...

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Hlavní autoři: Pollak, Nina M., Schweiger, Martina, Jaeger, Doris, Kolb, Dagmar, Kumari, Manju, Schreiber, Renate, Kolleritsch, Stephanie, Markolin, Philipp, Grabner, Gernot F., Heier, Christoph, Zierler, Kathrin A., Rülicke, Thomas, Zimmermann, Robert, Lass, Achim, Zechner, Rudolf, Haemmerle, Guenter
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2013
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605985/
https://ncbi.nlm.nih.gov/pubmed/23345410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M034710
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