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The aged niche disrupts muscle stem cell quiescence

The niche is a conserved regulator of stem cell quiescence and function. During aging, stem cell function declines. To what extent and by which means age-related changes within the niche contribute to this phenomenon are unknown. We demonstrate that the aged muscle stem cell niche, the muscle fiber,...

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Bibliographic Details
Main Authors: Chakkalakal, Joe V., Jones, Kieran M., Basson, M. Albert, Brack, Andrew S.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605795/
https://ncbi.nlm.nih.gov/pubmed/23023126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11438
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