Alteration of Plasma Membrane Organization by an Anticancer Lysophosphatidylcholine Analogue Induces Intracellular Acidification and Internalization of Plasma Membrane Transporters in Yeast

The lysophosphatidylcholine analogue edelfosine is a potent antitumor lipid that targets cellular membranes. The underlying mechanisms leading to cell death remain controversial, although two cellular membranes have emerged as primary targets of edelfosine, the plasma membrane (PM) and the endoplasm...

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Autores principales: Czyz, Ola, Bitew, Teshager, Cuesta-Marbán, Alvaro, McMaster, Christopher R., Mollinedo, Faustino, Zaremberg, Vanina
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Lipids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605658/
https://ncbi.nlm.nih.gov/pubmed/23344949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.425744
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