Alteration of Plasma Membrane Organization by an Anticancer Lysophosphatidylcholine Analogue Induces Intracellular Acidification and Internalization of Plasma Membrane Transporters in Yeast

The lysophosphatidylcholine analogue edelfosine is a potent antitumor lipid that targets cellular membranes. The underlying mechanisms leading to cell death remain controversial, although two cellular membranes have emerged as primary targets of edelfosine, the plasma membrane (PM) and the endoplasm...

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Bibliografiska uppgifter
Huvudupphovsmän: Czyz, Ola, Bitew, Teshager, Cuesta-Marbán, Alvaro, McMaster, Christopher R., Mollinedo, Faustino, Zaremberg, Vanina
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Lipids
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605658/
https://ncbi.nlm.nih.gov/pubmed/23344949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.425744
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